Understanding how the brain produces behavior is a guiding idea in neuroscience. Thus, establishing an interrelation between the brain and moral behavior has a long history in brain research. However, linking the brain with moral agency is tricky both with respect to the scientific endeavor as to therapy and rehabilitation of patients affected by brain lesions or neuromodulation interventions. Most of these interventions do not target moral or social behavior per se, but behavior changes with a moral or social connotation may result as mostly unintended side effects. This study outlines the complexity of the relationship between the brain and moral behavior and discusses ethical issues with a particular focus on neuromodulation in clinical settings. Brain interventions with a therapeutic aim affect the human being as a whole. Therefore, their ethical evaluation requires a broad approach that goes beyond a mere individualistic focus. This is due to the fact that moral behavior is a genuine social phenomenon.
